
The Collage Post Image by Pexels from Pixabay
The Collage Post
“Care studentesse e cari studenti,
come virologi del Dipartimento di Scienze Veterinarie sentiamo il dovere di esprimere e farvi conoscere la nostra opinione su quanto sta accadendo sul nostro territorio. Chi di voi ha già frequentato le nostre lezioni di virologia e malattie virali conosce l’approccio che utilizziamo quando vi parliamo delle infezioni epidemiche e di quali strategie i virus adottano per sfruttare la popolazione animale e mantenersi in natura.
Abbiamo a che fare con un virus ad RNA con una forte propensione a mutare ed adattarsi. L’origine è sicuramente animale ed il pipistrello è la specie serbatoio più probabile (alberga numerosi betacoronavirus fra cui quello da cui ha originato il virus della SARS). È probabile che sia passato all’uomo già da un po’ di tempo e si sia adattato (abbia imparato) proprio attraverso le mutazioni, ad essere trasmesso nel circuito interumano. Il salto di specie garantisce ad un nuovo virus un notevole vantaggio verso la popolazione suscettibile. L’uomo quindi rappresenta una opportunità formidabile perché rappresenta una specie abbondante, che vive in promiscuità ed è sprovvisto di memoria immunologica. I coronavirus del raffreddore sono degli alfacoronavirus e condividono ben poco del Covid 2019 in termini di cross-protezione. Quindi non è attesa in tempi brevi una riduzione della virulenza. Solo quando l’immunità di popolazione avrà raggiunto un certo livello, allora il virus comincerà ad essere trasmesso con maggiore difficoltà e tenderanno ad aumentare le forme lievi, croniche o asintomatiche. Notate che queste sono già presenti nella maggior parte degli infetti ma abbiamo ancora un 15-20% di infetti che sviluppano forme gravi che richiedono l’ospedalizzazione.
Una caratteristica di questo virus è quella di essere molto contagioso. Il legame con il recettore cellulare è venti volte più forte rispetto al virus della SARS. Inoltre presenta siti per le proteasi cellulari simili a quelli dei virus influenzali associati a peste aviare ad alta patogenicità (furin-like) quindi potenzialmente in grado di dare forme a maggior tropismo tissutale, essendo queste proteasi espresse in molti tessuti.
Quindi per concludere il virus non è la peste nera ma non è neanche una banale influenza e vi spieghiamo perché:
1) L’influenza stagionale ha una mortalità di circa lo 0,1%, non banale, ma la popolazione è in gran parte immune (per pregresse infezioni, parzialmente cross-protettive verso le nuove varianti e per la vaccinazione). In un tale contesto il virus influenzale serpeggia fra la popolazione e colpisce una frazione minoritaria delle persone senza incidere in modo significativo sulla forza lavoro di un paese.2) SARS-Cov2 è un virus nuovo. Non abbiamo memoria immunologica o immunità di gregge. In tali casi il virus, senza misure di controllo, avrebbe un andamento epidemico, arrivando ad interessare una larga fascia della popolazione recettiva (dove il denominatore è tutta la popolazione italiana) prima di cominciare a rallentare la progressione. Questo significa che, anche in assenza di
forme gravi, una gran parte della popolazione in età lavorativa, sarebbe bloccata per settimane con immaginabili ripercussioni sull’economia nazionale. Quindi ben vengano le misure di restrizione attualmente in uso per arginare almeno i principali focolai epidemici.
3) Covid-2019 causa forme gravi che richiedono il ricovero nel 15% dei casi. Si tratta di polmoniti che vengono curate in terapia intensiva per diversi giorni con l’ausilio della respirazione assistita. Quindi poco importa se la categoria a rischio di decesso siano gli over settantenni, con tutto il rispetto per i nostri vecchi. Anche i quarantenni o i cinquantenni (una parte cospicua della forza lavoro) avrebbe necessità della stessa terapia. Provate a chiedervi quanti letti per terapia intensiva ci sono nelle province italiane e quanti di questi sono già giustamente occupati da pazienti che hanno subito operazioni chirurgiche, traumi, ustioni ecc. Da qui la necessità di applicare tutte le misure utili ad arginare l’espandersi dei focolai epidemici, anche se vengono percepite come eccessive.
L’appello che facciamo agli studenti che hanno già maturato una sensibilità e coscienza sulle misure di lotta alle malattie degli animali è quella di fare tesoro delle vostre conoscenze ed essere parte attiva nella comunicazione del rischio, senza allarmare eccessivamente ma senza sottovalutare il problema.
Vi sarete accorti che non tutti i virologi che quotidianamente affollano le trasmissioni televisive la pensano allo stesso modo. Questo è assolutamente normale (la scienza è democratica fra gli scienziati e sensibilità e approcci diversi sono il sale del dibattito scientifico). La verità è che nessuno conosce come andrà a finire. Il principio di precauzione, se applicato bene, non sarà mai apprezzato abbastanza, se il problema sanitario poi non si verifica. Mentre una sottovalutazione del pericolo, in presenza di un’epidemia fuori controllo, farebbe scoppiare la rivoluzione. La difficoltà di prendere la giusta decisione è un sottile filo che lega questi due estremi.
Sergio Rosati, professore ordinario, Malattie infettive degli animali
Luigi Bertolotti, professore associato
Dipartimento di Scienze Veterinarie, Università di Torino
Hello, I enjoy reading all of your post. I wanted to write a little comment to support you.|
Very nice post. I just stumbled upon your blog and wished to say that I have truly enjoyed browsing your blog posts. In any case I’ll be subscribing to your feed and I hope you write again very soon!|
I was excited to uncover this great site. I need to to thank you for your time due to this fantastic read!! I definitely really liked every little bit of it and I have you saved to fav to check out new stuff in your site.|
thanks to all of the nice words they made me very happy.
excellent
Hello! Do you know if they make any plugins to help with SEO? I’m trying to get my blog to rank for some targeted keywords but I’m not seeing very good results. If you know of any please share. Appreciate it!|
Hi to all, how is everything, I think every one is getting more from this website, and your views are pleasant in support of new users.|
Awesome issues here. I am very satisfied to look your article. Thanks so much and I am looking forward to contact you. Will you please drop me a mail?|
Mi può contattare a queste mail postmaster@thecollagepost.it
Thank you
What’s up, after reading this remarkable paragraph i am also glad to share my know-how here with friends.|
These are actually fantastic ideas in on the topic of blogging. You have touched some good things here. Any way keep up wrinting.|
whoah this blog is fantastic i like reading your posts. Stay up the good work! You recognize, many people are hunting round for this info, you could aid them greatly. |
Appreciating the dedication you put into your blog and in depth information you present. It’s awesome to come across a blog every once in a while that isn’t the same out of date rehashed material. Excellent read! I’ve bookmarked your site and I’m including your RSS feeds to my Google account.|
We are a group of volunteers and opening a new scheme in our community. Your website offered us with valuable info to work on. You have done a formidable job and our whole community will be grateful to you.|
i like your blog
Thanks for sharing your thought
I am actually thankful to the owner of this web page who has shared this great article at here.|
hey there and thank you for your info – I’ve certainly picked up something new from right here. I did however expertise some technical issues using this site, as I experienced to reload the website a lot of times previous to I could get it to load properly. I had been wondering if your hosting is OK? Not that I am complaining, but slow loading instances times will very frequently affect your placement in google and could damage your high quality score if advertising and marketing with Adwords. Anyway I am adding this RSS to my email and could look out for a lot more of your respective intriguing content. Make sure you update this again very soon.|
Excellent website you have here but I was curious if you knew of any user discussion forums that cover the same topics talked about in this article? I’d really like to be a part of community where I can get responses from other experienced people that share the same interest. If you have any recommendations, please let me know. Thanks!|
My partner and I stumbled over here from a different web address and thought I should check things out. I like what I see so i am just following you. Look forward to going over your web page yet again.|
Hi there, this weekend is nice designed for me, since this moment i am reading this impressive informative article here at my house.|
Thanks you
Having read this I believed it was rather enlightening. I appreciate you finding the time and energy to put this article together. I once again find myself spending way too much time both reading and posting comments. But so what, it was still worth it!|
I do agree with all the concepts you’ve introduced to your post. They’re really convincing and can certainly work. Nonetheless, the posts are very short for beginners. Could you please extend them a little from next time? Thanks for the post.|
Heya i’m for the first time here. I found this board and I find It truly useful & it helped me out a lot. I hope to give something back and help others like you helped me.|
Hey I am so happy I found your blog page, I really found you by error, while I was searching on Digg for something else, Regardless I am here now and would just like to say thanks for a marvelous post and a all round interesting blog (I also love the theme/design), I don’t have time to go through it all at the minute but I have bookmarked it and also included your RSS feeds, so when I have time I will be back to read much more, Please do keep up the superb b.|
It’s awesome in favor of me to have a web site, which is helpful in support of my knowledge. thanks admin|
I blog often and I genuinely appreciate your information. The article has really peaked my interest. I am going to book mark your site and keep checking for new details about once per week. I opted in for your RSS feed as well.|
It’s not my first time to go to see this web site, i am visiting this web page dailly and take nice data from here daily.|
Incredible points. Sound arguments. Keep up the good work.|
It is not my first time to go to see this web site, i am browsing this website dailly and obtain nice facts from here daily.|
Hi there everyone, it’s my first pay a visit at this web page, and article is in fact fruitful for me, keep up posting these posts.|
Greetings! Very helpful advice within this post! It is the little changes that produce the biggest changes. Thanks for sharing!|
Its like you read my mind! You seem to know so much about this, like you wrote the book in it or something. I think that you could do with some pics to drive the message home a bit, but instead of that, this is great blog. An excellent read. I’ll definitely be back.|
Hi, this weekend is good designed for me, for the reason that this occasion i am reading this wonderful educational post here at my house.|
This design is incredible! You obviously know how to keep a reader amused. Between your wit and your videos, I was almost moved to start my own blog (well, almost…HaHa!) Wonderful job. I really enjoyed what you had to say, and more than that, how you presented it. Too cool!|
Hey there! I’m at work surfing around your blog from my new iphone 4! Just wanted to say I love reading your blog and look forward to all your posts! Carry on the fantastic work!|
I know this if off topic but I’m looking into starting my own weblog and was curious what all is required to get set up? I’m assuming having a blog like yours would cost a pretty penny? I’m not very web savvy so I’m not 100 sure. Any recommendations or advice would be greatly appreciated. Many thanks|
Hmm it appears like your site ate my first comment (it was super long) so I guess I’ll just sum it up what I submitted and say, I’m thoroughly enjoying your blog. I as well am an aspiring blog blogger but I’m still new to the whole thing. Do you have any tips and hints for rookie blog writers? I’d really appreciate it.|
Hello there, You have done a fantastic job. I will certainly digg it and individually suggest to my friends. I’m confident they will be benefited from this web site.|
Hello there, I discovered your website via Google even as looking for a comparable topic, your site came up, it appears to be like good. I have bookmarked it in my google bookmarks.
What’s up colleagues, nice piece of writing and good arguments commented here, I am genuinely enjoying by these.|
Hello colleagues, pleasant post and fastidious arguments commented here, I am truly enjoying by these.|
I got this web page from my pal who informed me on the topic of this website and now this time I am browsing this web page and reading very informative posts at this time.|
Your method of describing all in this post is in fact nice, every one can effortlessly understand it, Thanks a lot.|